产品编号：L486500

产品规格：50mg

产品价格：面议

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产品详情

标准品编号:	L486500
名称:	LY 2228820
别名:	5-[2-(1,1-Dimethylethyl)-5-(4-fluorophenyl)-1H-imidazol-4-yl]-3-(2,2-dimethylpropyl)-3H-imidazo[4,5-b]pyridin-2-amine Dimethanesulfonate;
CAS号:	862507-23-1
参考CAS号:	freeamine: 862505-00-8
分子式:	C₂₆H₃₇FN₆O₆S₂
分子量:	612.74
种类:	Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	LY2228820 is a novel and potent p38MAPK inhibitor with potent antiinflammatory activity. LY2228820 significantly inhibited phosphorylation of MAPKAPK2 and/or HSP27, down stream targets of p38MAPK, in both multiple myeloma (MM) cell lines and LT-BMSCs. LY2228820 is a potential candidate to improve MM patient outcome both by enhancing the effect of Bortezomib (B675700) and by reducing osteoskeletal events.
参考文献	Zhao, R. et al.: Drug Metab. Disp., 37, 1251 (2009); Ishitsuka, K. et al.: Br. J. Haematol., 141, 598 (2008); Mader, M. et al.: Bioorg. Med. Chem. Lett., 18, 179 (2008);