产品编号：L744832

产品规格：5mg

产品价格：面议

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产品详情

标准品编号:	L744832
名称:	L-744832
别名:	(2S)-[(2S)-[(2R)-Amino-3-mercapto]-propylamino-(3S)-methyl]pentyloxy-3-phenylpropionyl-methionine Sulfone Isopropyl Ester Bis Hydrchloride;
CAS号:	1177806-11-9
参考CAS号:	freebase: 1178093-87-2
分子式:	C₂₆H₄₇Cl₂N₃O₆S₂
外观:	白色固体
熔点:	160-165°C
分子量:	632.7
储存:	-20°C Freezer
溶解度:	DMSO (Slightly), Methanol (Slightly)
种类:	Standards; Enzyme Activators and Inhibitors;
应用:	Ras farnesyltransferase inhibitor. Induces tumor regression in transgenic mice with multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis. Induces p21 expressoin and arrests cells at G1. Causes enhanced mitotic sensitivity to taxol.
参考文献	Barrington, R.E., et al.: Mol. Cell. Biol., 18, 85 (1998, Sepp-Lorenzo, L. and Rosen, N.: J. Biol. Chem., 273, 20243 (1998), Moasser, M.M., et al.: Proc. Natl. Acad. Sci. USA, 95, 1369 (1998), Law, B.K., et al.: J. Biol. Chem., 275, 10796 (2000),