产品编号：O287590

产品规格：5mg

产品价格：面议

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产品详情

标准品编号:	O287590
名称:	Octyl-α-hydroxyglutarate
别名:	Octyl-2-HG;
分子式:	C₁₃H₂₄O₅
分子量:	260.33
类别:	Standards; Enzyme Activators and Inhibitors;
应用:	Octyl-α-hydroxyglutarate is a cell-permeable derivative of 2-HG (α-hydroxyglutaric acid). Mutations in isocitrate dehydrogenase 1 (IDH1 and IDH2) associated with certain cancers cause isocitrate to metabolize into 2-HG as opposed α-ketoglutarate, inhibiting α-ketoglutarate-dependant dioxygenases including lysine demethylases and DNA hydroxylases. This compound is suitable for IDH (isocitrate dehydrogenase) related research.
参考文献	Struys, E. et al.: Clin. Chem., 49, 1133 (2003); Ward, P. et al.: Cancer Cell., 17, 225 (2010);