产品编号：P132000
产品规格：10 mg
产品价格：面议
| 标准品编号: | P132000 |
| 名称: | PAC-1 |
| 别名: | 4-(Phenylmethyl)-1-piperazineacetic Acid 2-[[2-Hydroxy-3-(2-propen-1-yl)phenyl] methylene]hydrazide; Procaspase Activating Compound 1 |
| CAS号: | 315183-21-2 |
| 分子式: | C₂₃H₂₈N₄O₂ |
| 分子量: | 392.49 |
| 类别: | Research Tools; Pharmaceutical/API Drug Impurities/Metabolites; |
| 应用: | PAC-1 is a caspase 3 activator. Caspase activation is a key strategy in cancer therapy. Caspase 3 is a key executioner caspase and direct effector of apoptosis. Hallmark of many cancers is the circumvention of signal in the activation of executioner caspases and loss of apoptotic response. EC50 for caspase 3 activation = 0.33 μM and caspase 7= 4.5 μM. The IC50 for apoptosis induction = 0.92 μM. Elevated caspase 3 level in cancerous cell lines and tissues allows PAC-1 to selectively induce apoptosis in tissues. |
| 危险品: | Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package |
| 参考文献 | |
