产品编号：P293750

产品规格：100mg

产品价格：面议

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产品详情

标准品编号:	P293750
名称:	PF 184
别名:	8-[[[5-Chloro-2-[3,4-dimethyl-3,4-bis(hydroxymethyl)-1-pyrrolidinyl]-4-pyridinyl]carbonyl]amino]-1-(4-fluorophenyl)-4,5-dihydro-1H-benz[g]indazole-3-carboxamide;
CAS号:	1187460-81-6
分子式:	C₃₂H₃₂ClFN₆O₄
分子量:	619.09
类别:	Research Tools;
应用:	PF 184 is a potent and selective IKK-2 inhibitor (IC50 = 37 nM). Displays selectivity over 85 other kinases. Inhibits IL-1β-induced TNF-α in a steroid-insensitive in vitro model of oxidative stress.
参考文献	Baldwin, A., et al.: J. Clin. Invest., 107, 3 (2001), Adcock, I., et al.: Eur. J. Pharmacol., 533, 118 (2006), Sommers, et al.: J. Pharmacol. Exp. Ther., 330 377 (2009),