产品编号：P552525

产品规格：5mg

产品价格：面议

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产品详情

标准品编号:	P552525
名称:	Pixantrone Bismaleinamide
别名:	(2Z,2'Z)-4,4'-((((5,10-Dioxo-5,10-dihydrobenzo[g]isoquinoline-6,9-diyl)bis(azanediyl))bis(ethane-2,1-diyl))bis(azanediyl))bis(4-oxobut-2-enoic Acid)
分子式:	C₂₅H₂₃N₅O₈
分子量:	521.48
类别:	Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	Pixantrone Bismaleinamide is an impurity of Pixantrone (P552500), an antineoplastic drug belonging to group of antitumor antibiotics. Pixantrone is an anlogue of Mitoxantrone (M373425) and is just as potent in the treatment of multiple sclerosis with fewer toxic effects on cardiac tissue. Studies suggest that Pixantrone significantly reduces amyloid beta (A beta(1-42)) neurotoxicity, a mechanism implicated in Alzheimer's disease.
参考文献	Cavalletti, E. et al.: Invest. New Drugs, 25, 187 (2007); Gonsette, R.E. et al.: J. Neurol. Sci., 223, 81 (2004); Colombo, R. et al.: Electrophoresis, 30, 1418 (2009)