产品编号：R142810

产品规格：25mg

产品价格：面议

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产品详情

标准品编号:	R142810
名称:	1-epi Regadenoson
别名:	1-(6-Amino-9-((2S,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-2-yl)-N-methyl-1H-pyrazole-4-carboxamide;
CAS号:	2015222-31-6
分子式:	C₁₅H₁₈N₈O₅
分子量:	390.35
类别:	Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	1-epi Regadenoson is an epimer of Regadenoson (R142800). Regadenoson is a selective and potent A2A adenosine receptor agonist (1). The adenosine A2A receptor is a G-protein-coupled receptor and a key therapeutic target for oncologic, inflammatory, Parkinson's and cardiovascular diseases (2). In rodent studies, it has been shown that co-administration of Regadenoson with Temozolomide (T017775) can increase Temozolomide concentration in the brain (3).
参考文献	Gao, Z., et al.: J Pharmacol Exp Ther. 298, 209 (2001), Yuan, G., et al.: Expert Opin Drug Discov. 10, 63 (2015), Jackson, S., et al.: J Neurooncol. 126, 433 (2016)