产品编号：R425060
产品规格：1mg
产品价格：面议
| 标准品编号: | R425060 |
| 名称: | Romidepsin |
| 别名: | Cyclo[(2Z)-2-amino-2-butenoyl-L-valyl-(3S,4E)-3-hydroxy-7-mercapto-4-heptenoyl-D-valyl-D-cysteinyl] Cyclic (35)-Disulfide; [S-(E)]-N-(3-Hydroxy-7-mercapto-1-oxo-4- heptenyl)-D-valyl-D-cysteinyl-(Z)-2,3-didehydro-2-aminobutanoyl-L-valine (4-1)-Lactone Cyclic (12)-Disulfide; Antibiotic FR 901228; Chromadax; FK 228; FR 901228; NSC 630176; |
| CAS号: | 128517-07-7 |
| 分子式: | C₂₄H₃₆N₄O₆S₂ |
| 外观: | 白色至白色固体 |
| 熔点: | 219-224°C |
| 分子量: | 540.7 |
| 储存: | Amber Vial, -20°C Freezer, Under Inert Atmosphere |
| 溶解度: | Chloroform (Slightly), Methanol (Slightly) |
| 类别: | Standards; Enzyme Activators and Inhibitors; Others; Pharmaceutical/API Drug Impurities/Metabolites; Antibotics; |
| 应用: | Romidepsin is a histone deacetylase inhibitor that can alter chromatin structure and gene transcription leading to multiple changes in cellular protein production. This may result in cell cycle arrest and tumor growth inhibition. Romidepsin has shown anti-proliferative activity in vitro against multiple mouse and human tumor cell lines and in vivo in human tumor xenograft models. Romidepsin can be administered with a second agent, such as a cytotoxic agent, a steroidal agent, a proteasome inhibitor, or a kinase inhibitor. |
| 参考文献 | |
