产品编号：S154680

产品规格：100mg

产品价格：面议

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产品详情

标准品编号:	S154680
名称:	SB-505124
别名:	2-[5-(1,3-Benzodioxol-5-yl)-2-(1,1-dimethylethyl)-1H-imidazol-4-yl]-6-methylpyridine;
CAS号:	694433-59-5
参考CAS号:	356559-13-2 HCl salt
分子式:	C₂₀H₂₁N₃O₂
类别:	Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	SB-505124 is a selective inhibitor of transforming growth factor-beta type I receptor ALK5 and as well as being a selective inhibitor of ALK4 but with less potency. SB-505124 blocks TGF-β–induced apoptosis of FaO cells and NRP 154 cells in a concentration-dependent manner. SB-505124 has been shown to suppress the migration and invasion of breast cancer MCF-7-M5 cells.
参考文献	Goto, N. et al.: Cancer Sci., 102, 1501 (2011); DaCosta, B.S. et al.: Mol Pharmacol., 65, 744 (2004);