产品编号：S253800
产品规格：5mg
产品价格：面议
| 标准品编号: | S253800 |
| 名称: | Selonsertib |
| 别名: | 5-(4-Cyclopropyl-1H-imidazol-1-yl)-2-fluoro-4-methyl-N-[6-[4-(1-methylethyl)-4H-1,2,4-triazol-3-yl]-2-pyridinyl]benzamide; 5-(4-Cyclopropyl-1H-imidazol-1-yl)-2-fluoro-4-methyl-N-{6-[4-(propan-2-yl)-4H-1,2,4-triazol-3-yl]pyridin-2-yl}benzamide; GS 4977; GS 4997; |
| CAS号: | 1448428-04-3 |
| 分子式: | C₂₄H₂₄FN₇O |
| 外观: | 白色至淡黄色固体 |
| 熔点: | >180°C (dec.) |
| 分子量: | 445.49 |
| 储存: | 冰箱 |
| 溶解度: | DMSO (Slightly), Methanol (Slightly) |
| 类别: | Standards; Enzyme Activators and Inhibitors; |
| 应用: | Selonsertib is an apoptosis signal-regulating kinase 1 (ASK1) inhibitor with potential anti-inflammatory, antineoplastic and anti-fibrotic activities. Selonsertib interacts with the catalytic kinase domain of ASK1 and prevents its phosphorylation and activation. As a result, the expression of genes involved in fibrosis, cellular proliferation, and apoptosis are down regulated. |
| 参考文献 | |
