产品编号：S255600

产品规格：5mg

产品价格：面议

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产品详情

标准品编号:	S255600
名称:	Semagacestat
别名:	(2S)-2-Hydroxy-3-methyl-N-[(1S)-1-methyl-2-oxo-2-[[(1S)-2,3,4,5-tetrahydro-3-methyl-2-oxo-1H-3-benzazepin-1-yl]amino]ethyl]butanamide; LY 450139;
CAS号:	425386-60-3
分子式:	C₁₉H₂₇N₃O₄
外观:	白色固体
熔点:	213-215°C
分子量:	361.44
储存:	-20˚C Freezer
溶解度:	DMSO (Slightly), Dichloromethane (Slightly), Methanol (Slightly)
类别:	Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	Semagacestat is an inhibitor of the γ-secretase enzyme. γ-Secretase enzyme is pivotal in the generation of β-amyloid (Aβ), a neurotoxic endogenous peptide believed to be involved in the pathogenesis of Alzheimer's disease (AD).
参考文献	Portelius, E. et al.: Alzheim. Res. Ther., 22. No pp. given (2010); Imbimbo, B.P. et al.: Curr. Opin. Invest. Drugs, 10, 721 (2009); Panza, F. et al.: Curr. Med. Chem., 18, 5430 (2011);