产品编号：R701115

产品规格：10mg

产品价格：面议

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产品详情

标准品编号:	R701115
名称:	RTI 70
别名:	[1R-(exo,exo)]-3-(4-Chlorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic Acid; (1R,2S,3S,5S)-3-(4-Chlorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic Acid; N-Methyl-2β-carboxy-3β-(4-chlorophenyl)tropane; RTI 4229-70;
CAS号:	140633-58-5
分子式:	C₁₅H₁₈ClNO₂
分子量:	279.76
类别:	Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	RTI 70 is a cocaine derivative that prevent cocaine and MK-801 inhibition of nicotinic acetylcholine receptor (nAChR). Also, it is an intermediate used in the synthesis of RTI-113 (R701110), which is a 3-phenyltropane analogue that acts as a potent and selective dopamine uptake inhibitor. RTI-113 has been shown to reduce cocaine self-administration at high occupancy of dopamine transporter. Studies suggest that RTI-113 and its analogs may be useful tools for developing potential agonist therapies for cocaine dependence.
参考文献	Hess, G. P., et al.: Biochem., 42, 6106-6114 (2003); Dworkin, S. et al.: Synapse, 30, 49 (1998); Negus, S.S. et al.: Pharmacol. Biochem. Behav., 91, 333 (2009); Cook, C. et al.: Eur. J. Pharmacol., 442, 93 (2002);