产品编号：R701120

产品规格：25mg

产品价格：面议

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产品详情

标准品编号:	R701120
名称:	RTI-COC 31
别名:	[1R-(exo,exo)]-3-(4-Chlorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic Acid Methyl Ester; O 371;
CAS号:	130342-80-2
分子式:	C₁₆H₂₀ClNO₂
外观:	白色固体
熔点:	116-119°C
分子量:	293.79
储存:	Hygroscopic, -20°C Freezer, Under inert atmosphere
溶解度:	Chloroform (Slightly), Methanol (Sparingly)
稳定性:	Hygroscopic
类别:	Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	RTI-COC 31 is a potent phenyltropane cocaine analog which exhibits inhibitory interactions with serotonergic neurons. Also, it is an intermediate used in the synthesis of RTI-113 (R701110), which is a 3-phenyltropane analogue that acts as a potent and selective dopamine uptake inhibitor. RTI-113 has been shown to reduce cocaine self-administration at high occupancy of dopamine transporter. Studies suggest that RTI-113 and its analogs may be useful tools for developing potential agonist therapies for cocaine dependence.
参考文献	Lakoski, J. M., et al.: Med. Sci. Symp. Ser., 5, 359-365 (1993); Dworkin, S. et al.: Synapse, 30, 49 (1998); Negus, S.S. et al.: Pharmacol. Biochem. Behav., 91, 333 (2009); Cook, C. et al.: Eur. J. Pharmacol., 442, 93 (2002);