产品编号：S699222

产品规格：10mg

产品价格：面议

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产品详情

标准品编号:	S699222
名称:	Sulindac Sulfide-d6 (Major)
别名:	(Z)-5-Fluoro-2-methyl-1-[p-(methylthio)benzylidene]indene-3-acetic Acid-d6;
参考CAS号:	类似: 49627-27-2
分子式:	C₂₀H₁₁D₆FO₂S
分子量:	346.45
类别:	Building Blocks; Isotopic Labeled Analogues;
应用:	Labelled analogue of Sulindac Sulfide, an active metabolite of Sulindac. Inhibits cyclooxygenase, but induces apoptosis by a cyclooxygenase-independent mechanism. Inhibition of Ras activation of Ref-1. Impairs nucleotide exchange on Ras by CDC25 and accelerates Ras hydrolysis of GTP by p120GAP.
参考文献	Hermann, C., et al.: Oncogene, 17, 1769 (1998); Lim, T.J., et al.: Biochem. Pharmacol., 58, 1097 (1999); Zhang, Z. and DuBois, R.N.: Gastroenterology, 118, 1012 (2000);