产品编号：S836043

产品规格：2.5mg

产品价格：面议

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产品详情

标准品编号:	S836043
名称:	SAK3
别名:	SAK 3; Ethyl 8'-methyl-2',4-dioxo-2-(piperidin-1-yl)-2'H-spiro[cyclopent[2]ene-1,3'-imidazo[1,2-a]pyridine]-3-carboxylate; Ethyl 8′-methyl-2′,4-dioxo-2-(piperidin-1-yl)-2′H-spiro[cyclopent[2]ene-1,3′-imidazo[1,2-a]pyridine]-3-carboxylate
CAS号:	1256269-87-0
分子式:	C₂₀H₂₃N₃O₄
分子量:	369.41
类别:	Standards; Enzyme Activators and Inhibitors;
应用:	SAK3 is a potent CaV3.1 and CaV3.3 activator. Enhances CaV3.1 and CaV3.3, but not CaV3.2 activity at concentrations of 0.01 - 10 M in neuro2A cells in vitro. Elevates ACh levels in hippocampus. Rescues impaired memory-related behaviors in OBX mice. Orally bioavailable.
参考文献	Abe, Takashi., et al.: Heterocycles., 81,Â2075Â(2010); Yabuki, Y., et al.:Neuropharmacology, 117, 1-13. (2017)