产品编号：T005550

产品规格：10mg

产品价格：面议

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产品详情

标准品编号:	T005550
名称:	Talmapimod
别名:	6-Chloro-5-[[(2R,5S)-4-[(4-fluorophenyl)methyl]-2,5-dimethyl-1-piperazinyl]carbonyl]-N,N,1-trimethyl-α-oxo-1H-indole-3-acetamide; SCIO 469; Scios 469;
CAS号:	309913-83-5
分子式:	C₂₇H₃₀ClFN₄O₃
分子量:	513
类别:	Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	Talmapimod is a p38 mitogen-activated protein (MAP) kinase inhibitor. Talmapimod reduced human myeloma cell growth in vivo both at early and advanced phases of the disease in mouse xenograft models. Talmapimod that blocks tumor necrosis factor-α, interleukin-1β, and cyclooxygenase-2 synthesis in patients with active rheumatoid arthritis (RA)
参考文献	Medicherla, S. et al.: Antincancer Res., 28, 3827 (2008); Genovese, M.S. et al.: J. Rheumatol., 38, 846 (2011); Medicherla, S. et al.: J. Inflam. Res., 3, 9 (2010);