产品编号：T007600

产品规格：25mg

产品价格：面议

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产品详情

标准品编号:	T007600
名称:	Tariquidar
别名:	N-[2-[[[4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]amino]carbonyl]-4,5-dimethoxyphenyl]-3-quinolinecarboxamide; XR 9576;
CAS号:	206873-63-4
分子式:	C₃₈H₃₈N₄O₆
外观:	淡黄色固体
熔点:	>190ºC (dec.)
分子量:	646.73
储存:	冰箱
溶解度:	DMSO (Slightly), Methanol (Slightly)
类别:	Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	Tariquidar is a p-glycoprotein drug efflux pump inhibitor. Tariquidar inhibits the ATPase activity of P-glycoprotein, suggesting that the modulating effect is derived from the inhibition of substrate binding, inhibition of ATP hydrolysis or both.Tariquidar can be considered an ideal agent for testing the role of P-glycoprotein inhibition in cancer.
参考文献	Fox, E., et al.: Expert. Rev. Ainticancer. Ther., 7, 447 (2007); Hernandez, D., et al.: Biochem. Pharmacol., 85, 21 (2013); Bauer, F., et al.: Euro. J. Pharmacol., 696, 18 (2012);