产品编号：T117585

产品规格：10mg

产品价格：面议

---

产品详情

标准品编号:	T117585
名称:	(R)-(-)-tert-Butyl 2-(4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
别名:	(6R)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic Acid 1,1-Dimethylethyl Ester; (-)-JQ1
CAS号:	1268524-71-5
分子式:	C₂₃H₂₅ClN₄O₂S
分子量:	456.99
类别:	Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	(R)-(-)-Tert-butyl 2-(4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate is the enantiomer of (S)-(+)-Tert-butyl 2-(4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate (T117580), which is BET bromodomain inhibitor, also activates HIV latency through antagonizing Brd4 inhibition of Tat-transactivation.
参考文献	Li, Z.C., et al.: Nuc. Acids. Res., 41, 277 (2013); Hay, D., et al.: Med. Chem. Comm., 4, 140 (2013);