产品编号：T292885

产品规格：25mg

产品价格：面议

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产品详情

标准品编号:	T292885
名称:	6,7,8,8a-Tetrahydro-2H-naphtho[1,8-bc]furan-2-one
CAS号:	74145-12-3
分子式:	C₁₁H₁₀O₂
外观:	淡黄色固体
分子量:	174.2
储存:	Room Temperature
溶解度:	Dichloromethane; Methanol; Ethyl Acetate;
类别:	Building Blocks; Miscellaneous;
应用:	6,7,8,8a-Tetrahydro-2H-naphtho[1,8-bc]furan-2-one is an intermediate used in the synthesis of N-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-5,6-dihydro-1-Naphthalenecarboxamide (A795305), which is an impurity of Palonosetron (P165800), a serotonin 5-HT3 receptor antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). Antiemetic.
参考文献	Clark, R.D., et al.: J. Med. Chem., 36, 2645 (1993), Wong, E.H.F., et al.: Br. J. Pharmacol., 114, 851 (1995), Grunberg, S.M., et al.: Expert. Opin. Pharmacother., 4, 2297 (2003), Eisenberg, P., et al.: Ann. Oncol., 15, 330 (2004), Siddiqui, M.A.A., et al.: Drugs, 64, 1125 (2004),