产品编号：T338202

产品规格：

产品价格：面议

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产品详情

标准品编号:	T338202
名称:	TH-302-d8
别名:	N,N'-Bis(2-bromoethyl)phosphorodiamidic Acid-d8 (1-Methyl-2-nitro-1H-imidazol-5-yl)methyl Ester;
CAS号:	918632-75-4
参考CAS号:	Unlabelled: 918633-87-1
分子式:	C₉H₈D₈Br₂N₅O₄P
分子量:	457.09
类别:	Building Blocks; Isotopic Labeled Analogues;
应用:	TH-302-d8 is the isotope labelled analog of TH-302 (T338200), a 2-nitroimidazole triggered hypoxia-activated prodrug (HAP) of bromo-isophosphoramide mustard. Studies have shown that TH-302 treatment exhibited hypoxia-selective cytotoxicity and DNA damage in human cancer cell.
参考文献	Meng, F. et al.: Mol. Cancer Ther., 11, 740 (2012); Liu, Q. et al.: Cancer Chemother. Pharmacol., 69, 1487 (2012); Sun, J.D. et al.: Clin. Cancer Res., 18, 758 (2012);