产品编号：T345133

产品规格：250mg

产品价格：面议

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产品详情

标准品编号:	T345133
名称:	Thiazol-5-ylmethyl ((2S,3S,5S)-5-Amino-3-((tert-butyldimethylsilyl)oxy)-1,6-diphenylhexan-2-yl)carbamate
分子式:	C₂₉H₄₁N₃O₃SSi
外观:	Yellow Oil
分子量:	539.8
溶解度:	Dichloromethane;
类别:	Building Blocks; Chiral Molecules;
应用:	Thiazol-5-ylmethyl ((2S,3S,5S)-5-Amino-3-((tert-butyldimethylsilyl)oxy)-1,6-diphenylhexan-2-yl)carbamate is an intermediate in synthesizing Bis(thiazol-5-yl-methyl)[carbonylbis[imino[(2S,3S,5S)-3-hydroxy-1,6-diphenylhexane-5,2-diyl]]]dicarbamate (R535035). Ritonavir Impurity P is derived from 2S,3S,5S-5-Amino-2-[N-[[(5-thiozolyl)methoxy]carbonyl]amino]-1,6-diphenyl-3-hydroxyhexane (A630525), which is an intermediate in the synthesis of Ritonavir (R535000), a selective HIV protease inhibitor.
参考文献	Kempf, D., et al.: J. Med. Chem., 41, 602 (1998); Daluge, S., et al.: Antimicrob. Agents Chemother., 38, 1590 (1994); Ammaranond, P., et al.: J. Clin. Virol., 26, 153 (2003); Harrigan, P., et al.: J. Infect. Dis., 191, 339 (2005); Miller, J., et al.: Bioorg. Med. Chem. Lett., 16, 1788(2006)