产品编号：T548700

产品规格：25mg

产品价格：面议

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产品详情

标准品编号:	T548700
名称:	Torin 1
别名:	1-[4-[4-(1-Oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)benzo[h]-1,6-naphthyridin-2(1H)-one;
CAS号:	1222998-36-8
分子式:	C₃₅H₂₈F₃N₅O₂
外观:	白色至Off-Wite Solid
熔点:	>223°C (dec.)
分子量:	607.62
储存:	-20˚C Freezer
溶解度:	Chloroform, DMSO, Methanol (Sparigly)
类别:	Research Tools; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	Torin 1 is a potent and selective mTOR inhibitor (IC50 = 2 - 10 nM for mTORC1 and mTORC2). Displays 200-fold selectivity for mTOR over DNVIP(LA)PK, ATM and hVps34.
参考文献	Thoreen, et al.: J. Biol. Chem., 284, 8023 (2009), Liu, et al.: J. Med. Chem., 53, 7146 (2010), Peterson, et al.: Peterson, et al.: Cell, 146 408 (2011),

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