产品编号：V096300

产品规格：10mg

产品价格：面议

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产品详情

标准品编号:	V096300
名称:	L-Valyl-N-methyl-L-leucyl-L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-(2S,3R,4R,6E)-3-(acetyloxy)-4-methyl-2-(methylamino)-6-octenoyl-(2S)-2-aminobutanoyl-N-methyl-glycine Methyl Ester
别名:	L-Valyl-N-methyl-L-leucyl-L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-(3R,4R,6E)-3-(acetyloxy)-6,7-didehydro-N,4-dimethyl-L-2-aminooctanoyl-L-2-aminobutanoyl-N-methyl-glycine Methyl Ester
CAS号:	156047-45-9
分子式:	C₅₈H₁₀₄N₁₀O₁₃
外观:	Yellow Solid
分子量:	1149.51
溶解度:	Acetone, DCM, Methanol
类别:	Standards; Chiral Molecules; Amino Acids/Peptides; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	L-Valyl-N-methyl-L-leucyl-L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-(2S,3R,4R,6E)-3-(acetyloxy)-4-methyl-2-(methylamino)-6-octenoyl-(2S)-2-aminobutanoyl-N-methyl-glycine Methyl Ester is an intermediate in the synthesis of Cyclosporin AM 4N (C989410), a metabolite of Cyclosporin A (C988900). Cyclosporin A is a hydrophobic cyclic undecapeptide that is used as a potent immunosuppressive agent that has application in human organ transplantation. Cyclosporin A works by inhibiting subsets of T lymphocytes to facilitate organ transplantation.
参考文献	Brooks, C., et al.: Clin. Chem., 39, 457 (1993); Colombani, P., et al.: Science, 228, 337 (1985);Krönke, M., et al.: Proc. Nat. Acad. Sci., 81, 5214 (1984); Liu, J., et al.: Cell, 66, 807 (1991); Serino, F., et al.: Mol. Cell. Biochem., 122, 101 (1993)