产品编号：Y100200

产品规格：100mg

产品价格：面议

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产品详情

标准品编号:	Y100200
名称:	Y 11
别名:	1-(2-Hydroxyethyl)-3,5,7-triaza-1-azoniatricyclo[3.3.1.13,7]decane Bromide;
CAS号:	1086639-59-9
参考CAS号:	76044-75-2-free base
分子式:	C₈H₁₇BrN₄O
分子量:	265.15
类别:	Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	Y 11 is a potent inhibitor of focal adhesion kinase (FAK); Y 11 prevents FAK autophosphorylation at the Y397 site (IC50 ~ 50 nM in an in vitro kinase assay). Displays selectivity for FAK over a panel of other kinases (concentration used in assay = 1 μM). Y 11 decreases cell viability in a number of cancer cell lines; blocks colony formation in SW620 and BT474 cell lines.
参考文献	Xing, Z., et al.: Mol. Biol. Cell, 5, 413 (1994), Halder, J., et al.: Clin. Cancer Res., 11, 8829 (2005), Beierle, E., et al.: J. Biol. Chem., 282, 12503 (2007), Golubovskaya, et al.: J. Med. Chem., 51 7405 (2008),