产品编号：Y100700

产品规格：100mg

产品价格：面议

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产品详情

标准品编号:	Y100700
名称:	YE-120
别名:	2-[3-Cyano-5-(3,4-dichlorophenyl)-4,5-dimethyl-2(5H)-furanylidene]propanedinitrile; [3-Cyano-5-(3,4-dichlorophenyl)-4,5-dimethyl-2(5H)-furanylidene]propanedinitrile;
CAS号:	383124-82-1
分子式:	C₁₆H₉Cl₂N₃O
分子量:	330.17
类别:	Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	YE-120 is a GPR35 agonist (EC50 = 32 nM in DMR assays). YE-120 also displays partial agonist activity in a β-arrestin translocation assay (EC50 = 10.2 μM). GPR35 is a Class A, rhodopsin-like G protein-coupled receptor which is predominantly expressed in immune and gastrointestinal tissue, with notable expression in the ileum (rat and human GPR35), the spleen (rat and murine GPR35) and the pancreas (human GPR35).
参考文献	Okumura, S., et al.: Cancer Sci., 95, 131 (2004); Wang, J., et al.: J. Biol. Chem., 281, 22021 (2006); Yang, Y., et al.: Pharmacology, 86, 1 (2010); Deng, et al.: J. Med. Chem., 54 7385 (2011);