产品编号：Z487000
产品规格：2mg
产品价格：面议
| 标准品编号: | Z487000 |
| 名称: | ZM 447439 |
| 别名: | N-[4-[[6-Methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinazolinyl]amino]phenyl]benzamide; |
| CAS号: | 331771-20-1 |
| 分子式: | C₂₉H₃₁N₅O₄ |
| 外观: | 淡黄色固体 |
| 熔点: | >104°C |
| 分子量: | 513.59 |
| 储存: | 冰箱 |
| 溶解度: | DMSO, Methanol |
| 类别: | Research Tools; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites; |
| 应用: | It is a potent and selective inhibitor of Aurora B kinase. Cells treated with ZM-447439 progress through interphase, enter mitosis and assemble bipolar spindles but chromosome alignment, segregation and cytokinesis all fail. It induces apoptosos in Hep2 cancer cells and in acute myeloid leukemia cell lines but its propensity to induce polyploidy does not inevitably result in apoptosis. |
| 参考文献 | |
