Reversine, ≥98%(HPLC)
Product Name： Reversine
CAS号:656820-32-5
分子式:C21H27N7O
分子量:393.49
介绍： Reversine
贮存： 储存温度-20°C
可溶性： 25°C： DMSO
生化和生理学机理：
Description：
IC50 Value： 150 nM (Aurora Kinase A); 500 (Aurora Kinase B); 400 nM (Aurora Kinase C) [1]
Reversine, a small synthetic purine analogue (2,6-disubstituted purine), has been shown to be effective in tumor suppression. These effects of reversine are due to the inhibition of Aurora A and B.
in vitro： Reversine induced apoptosis in PDTC cells with caspase-3 and caspase-8 activation, but not caspase-9. Use of a pan-caspase inhibitor before treatment with reversine attenuated cell death [2]. Reversine significantly suppressed the proliferation of two OSCC cell lines (OC2 and OCSL) and markedly rendered cell cycle arrest at G2/M stage. Reversine also induced cell death via both caspase-dependent and -independent apoptosis. In addition,reversine could inhibit Akt/mTORC1 signaling pathway, accounting for its ability to induce autophagy [3]. Reversine pre-treatment, at very low concentration (50 nM), caused a marked increase in the differentiation yiel
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